Mantle cell lymphoma

B‑cell NHL with t(11;14) → cyclin D1 (CCND1) overexpression; typically older men; often disseminated at dx.

• More aggressive than other indolent B‑cell NHLs and frequently involves GI (lymphomatous polyposis).

• Older male with generalized lymphadenopathy + splenomegaly
• May have multiple GI polyps due to mucosal involvement

1. IHC: cyclin D1+, SOX11+ supports diagnosis
2. Distinguish from CLL/SLL (CD23+) and FL (BCL2 in follicles)

1. Rituximab‑based chemoimmunotherapy ± targeted agents (BTK inhibitors) depending on stage/fitness

• Mnemonic: 11 to 1 → t(11;14) drives D1 (cyclin D1)