Non‑Hodgkin lymphoma

Heterogeneous group of mostly B‑cell lymphomas (also T/NK) with non‑contiguous spread and frequent extranodal disease.

• Big umbrella that includes Burkitt, follicular, mantle, DLBCL, marginal zone, etc.

• Generalized lymphadenopathy ± extranodal sites (GI, skin, CNS)
• Immunocompromised states (HIV, post‑transplant), autoimmune disease

1. Biopsy and subclassify (IHC/genetics) → therapy depends on specific subtype
2. Look for hallmark translocations (MYC, BCL2, CCND1) to narrow dx